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2. Every day, 50 teenagers in Malaysia begin smoking. Of the 4.7 million smokers here, most started before the age of 18, with 25% before the age of 10. A study on juvenile delinquency carried out by the Malaysian Crime Prevention Foundation showed that cigarette smoking offence (87%) is the top of the seven offences among delinquent children. Making cigarettes affordable for our youths and children will clearly result in far greater repercussions than we can imagine. 3. Every year, more than 20,000 Malaysians are killed by tobacco-related diseases. Studies show that more men and women die in Malaysia from tobacco-related diseases than on average in middle-income countries. What is more alarming is that you don’t need to be a smoker to be at risk. The Global Adult Tobacco Survey 2012 on Malaysia revealed that four out of 10 adults were found to be exposed to secondhand smoke at home (7.6 million adults), and four out of 10 were found to be exposed to secondhand smoke indoors at their workplace (2.3 million adults).
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In these adults, 22–70 years of age, older smokers showed the most volume loss. Subcortical white matter (WM), thalamus, cerebellar cortex, and corpus callosum were most affected. Higher cigarette pack-years related to smaller volumes in several subcortical regions. Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined.